Kaethe Sandman
Adjunct Faculty, Biological Sciences
Department
- Biological and Env Science
Contact Information
- 614-236-6520
- ksandman2@capital.edu
- Battelle Hall 281
Classes
UC241 Science and Technology in Society
Biography
Kathleen M. Sandman received her B.A. in Biology from La Salle University and her Ph.D. in Cellular and Developmental Biology from Harvard University. She was inspired to a career in science by her older brother''s experience as an organic chemist and by the developing technology in recombinant DNA in the 1970s. Her graduate work used a transposable element as a mutagen in Bacillus subtilis to study gene expression during endospore formation. She continued in the genetics of Gram-positive bacteria with a postdoctoral year studying Bacillus thuringiensis at the University of Cambridge in the United Kingdom. Another postdoctoral opportunity at The Ohio State University provided an introduction to the emerging field of archaeal molecular biology, where Dr. Sandman discovered archaeal histones and continued research in the structural biology of archaeal chromatin for about 20 years. She served the National Science Foundation as a research grant reviewer and panelist for the Life in Extreme Environments program, and has organized conference sessions on archaeal molecular biology and proteins from extremophiles. Dr. Sandman has taught microbiology to hundreds of students, at both the introductory level and in an advanced molecular microbiology laboratory. Dr. Sandman has worked as a consultant in a variety of industries, including industrial microbiology, environmental geomicrobiology, and technical publishing. She lives with her husband in Columbus, Ohio and has two grown daughters.
Degrees Earned
BA Biology, La Salle University, Philadelphia PA
Ph.D. Cellular and Developmental Biology, Harvard University, Cambridge MA
Ph.D. Cellular and Developmental Biology, Harvard University, Cambridge MA
Publications
Stephens, M.A., N. Lang, K. Sandman and R. Losick. 1984. A promoter whose utilization is temporally regulated during sporulation in Bacillus subtilis. J. Mol. Biol. 176:333-348.
Youngman, P., J.B. Perkins and K. Sandman. 1984. New genetic methods, molecular cloning strategies and gene fusion techniques for Bacillus subtilis which take advantage of Tn917 insertional mutagenesis. In, Genetics and Biotechnology of Bacilli, eds. J. Hoch and A.T. Ganesan, Academic Press.
Youngman, P., P. Zuber, J.B. Perkins, K. Sandman, M. Igo and R. Losick. 1985. New ways to study developmental genes in spore-forming bacteria. Science 228:285-291.
Youngman, P., J.B. Perkins, and K. Sandman. 1985. Use of Tn917-mediated transcriptional gene fusions to lacZ and cat-86 for the identification and study of spo genes in Bacillus subtilis. In, Molecular Biology of Microbial Differentiation, eds. J. Hoch and P. Setlow, American Society for Microbiology.
Donovan, W.P., L.B. Zheng, K. Sandman and R. Losick. 1987. Genes encoding spore coat proteins from B. subtilis. J. Mol. Biol. 196:1-10.
Sandman, K., R. Losick and P. Youngman. 1987. Genetic analysis of Bacillus subtilis spo mutants generated by Tn917-mediated insertional mutagenesis. Genetics 117:603-617.
Sandman, K., L. Kroos, S. Cutting, P. Youngman and R. Losick. 1988. Identification of the promoter for a spore coat protein gene in Bacillus subtilis and studies on the regulation of its induction at a late stage of sporulation. J. Mol. Biol. 200:461-473.
Kunkel, B., K. Sandman, S. Panzer, P. Youngman and R. Losick. 1988. The promoter for a sporulation gene in the spoIVC locus of Bacillus subtilis and its use in studies of temporal and spatial control of gene expression. J. Bact. 170:3513-3522.
Sandman, K., J.A. Krzycki, B. Dobrinski, R. Lurz and J.N. Reeve. 1990. DNA binding protein HMf, isolated from the hyperthermophilic archaeon Methanothermus fervidus, is most closely related to histones. Proc. Natl. Acad. Sci. USA 87:5788-5791.
Krzycki, J.A., K. Sandman and J.N. Reeve. 1990. Purification and characterization of histone HMf from the hyperthermophilic archaebacterium Methanothermus fervidus. In Proceedings of the 6th International Symposium on Genetics of Industrial Microorganisms, eds. H. Heslot, J. Davies, J. Florent, L. Bobichon, G. Durand, L. Penasse, Societe Francaise de Microbiologie.
Musgrave, D.R., K. Sandman, D. Stroup and J.N. Reeve. 1991. DNA binding proteins and genome topology in thermophilic procaryotes. In Biocatalysis near or above 100°C, eds. M. Adams, R. Kelly, American Chemical Society.
... and many more
Youngman, P., J.B. Perkins and K. Sandman. 1984. New genetic methods, molecular cloning strategies and gene fusion techniques for Bacillus subtilis which take advantage of Tn917 insertional mutagenesis. In, Genetics and Biotechnology of Bacilli, eds. J. Hoch and A.T. Ganesan, Academic Press.
Youngman, P., P. Zuber, J.B. Perkins, K. Sandman, M. Igo and R. Losick. 1985. New ways to study developmental genes in spore-forming bacteria. Science 228:285-291.
Youngman, P., J.B. Perkins, and K. Sandman. 1985. Use of Tn917-mediated transcriptional gene fusions to lacZ and cat-86 for the identification and study of spo genes in Bacillus subtilis. In, Molecular Biology of Microbial Differentiation, eds. J. Hoch and P. Setlow, American Society for Microbiology.
Donovan, W.P., L.B. Zheng, K. Sandman and R. Losick. 1987. Genes encoding spore coat proteins from B. subtilis. J. Mol. Biol. 196:1-10.
Sandman, K., R. Losick and P. Youngman. 1987. Genetic analysis of Bacillus subtilis spo mutants generated by Tn917-mediated insertional mutagenesis. Genetics 117:603-617.
Sandman, K., L. Kroos, S. Cutting, P. Youngman and R. Losick. 1988. Identification of the promoter for a spore coat protein gene in Bacillus subtilis and studies on the regulation of its induction at a late stage of sporulation. J. Mol. Biol. 200:461-473.
Kunkel, B., K. Sandman, S. Panzer, P. Youngman and R. Losick. 1988. The promoter for a sporulation gene in the spoIVC locus of Bacillus subtilis and its use in studies of temporal and spatial control of gene expression. J. Bact. 170:3513-3522.
Sandman, K., J.A. Krzycki, B. Dobrinski, R. Lurz and J.N. Reeve. 1990. DNA binding protein HMf, isolated from the hyperthermophilic archaeon Methanothermus fervidus, is most closely related to histones. Proc. Natl. Acad. Sci. USA 87:5788-5791.
Krzycki, J.A., K. Sandman and J.N. Reeve. 1990. Purification and characterization of histone HMf from the hyperthermophilic archaebacterium Methanothermus fervidus. In Proceedings of the 6th International Symposium on Genetics of Industrial Microorganisms, eds. H. Heslot, J. Davies, J. Florent, L. Bobichon, G. Durand, L. Penasse, Societe Francaise de Microbiologie.
Musgrave, D.R., K. Sandman, D. Stroup and J.N. Reeve. 1991. DNA binding proteins and genome topology in thermophilic procaryotes. In Biocatalysis near or above 100°C, eds. M. Adams, R. Kelly, American Chemical Society.
... and many more